As you know hex spell can cause either physical disease (the first sign is weakness and irritation) or mental disorder (depression, sadness, fear). Even death. Hex spell can destroy families and make a lot of harm. Evil eye is the same as hex spell. It can ruin a person.
Family curse. If no boys are born in your family or they die in their early age. Every year or from time to time two or three relatives die under strange circumstances. Unfortunate married women etc. There are so many family curses and hexes that they can’t be counted. But it goes on and on from one generation to another.